Paulinho's injury was announced Tuesday, with The Times reporting that he's set to miss four weeks, which Tottenham subsequently confirmed. Younes Kaboul, Sandro, Andros Townsend and Jan Vertonghen are all still out. Jermain Defoe is being called a doubt for the game.
There's no news on Danny Rose, which we can only hope is good news. If the club isn't acknowledging an injury, it's likely that he was just rested against Stoke to make sure that he's fully fit to face Manchester United. It's also worth mentioning that Kyle Walker, who was suspended against Stoke, will return and probably start at right back.
On the Manchester United injury front, they're still going to be without Robin van Persie for Wednesday's match. Wayne Rooney will have to pass a late fitness test to play. Marouane Fellaini and Rafael are still out for a few more weeks, while Phil Jones and Nani aren't expected to be fit either. Antonio Valencia will be available after serving a suspension against Norwich.